Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.
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ABSTRACT:
SUBMITTER: May ER
PROVIDER: S-EPMC3274788 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.
May Eric R ER Feng Jun J Brooks Charles L CL
Biophysical journal 20120207 3
Many icosahedral viruses undergo large-scale conformational transitions between icosahedrally symmetric conformations during their life cycles. However, whether icosahedral symmetry is maintained along the transition pathways for this process is unknown. By employing a simplified and directed structure-based potential we compute an ensemble of transition pathways for the maturation transition of bacteriophage HK97. We observe localized symmetry-breaking events, but find that the large-scale disp ...[more]
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