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Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.

ABSTRACT: Many icosahedral viruses undergo large-scale conformational transitions between icosahedrally symmetric conformations during their life cycles. However, whether icosahedral symmetry is maintained along the transition pathways for this process is unknown. By employing a simplified and directed structure-based potential we compute an ensemble of transition pathways for the maturation transition of bacteriophage HK97. We observe localized symmetry-breaking events, but find that the large-scale displacements are dominated by icosahedrally symmetric deformation modes. We find that all pathways obey a common mechanism characterized by formation of pentameric contacts early in the transition.

SUBMITTER: May ER

PROVIDER: S-EPMC3274788 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.

May Eric R ER Feng Jun J Brooks Charles L CL

Biophysical journal 20120207 3

Many icosahedral viruses undergo large-scale conformational transitions between icosahedrally symmetric conformations during their life cycles. However, whether icosahedral symmetry is maintained along the transition pathways for this process is unknown. By employing a simplified and directed structure-based potential we compute an ensemble of transition pathways for the maturation transition of bacteriophage HK97. We observe localized symmetry-breaking events, but find that the large-scale disp ...[more]

PMID: 22325284

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Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.

Publications

Exploring the symmetry and mechanism of virus capsid maturation via an ensemble of pathways.

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