Ontology highlight
ABSTRACT:
SUBMITTER: Markiewicz MA
PROVIDER: S-EPMC3276246 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Markiewicz Mary A MA Wise Erica L EL Buchwald Zachary S ZS Pinto Amelia K AK Zafirova Biljana B Polic Bojan B Shaw Andrey S AS
Immunity 20120112 1
The mechanisms by which cytotoxic T lymphocytes (CTLs) enter and are retained in nonlymphoid tissue are not well characterized. With a transgenic mouse expressing the NKG2D ligand retinoic acid early transcript 1ε (RAE1ε) in β-islet cells of the pancreas, we found that RAE1 expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets. This was dependent on NKG2D expression by the CTLs and independent of antigen recognition. Surprisingly, the recruitment of CTLs re ...[more]