Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang J
PROVIDER: S-EPMC3276553 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Zhuang Joanna J Jones Allison A Lee Shih-Han SH Ng Esther E Fiegl Heidi H Zikan Michal M Cibula David D Sargent Alexandra A Salvesen Helga B HB Jacobs Ian J IJ Kitchener Henry C HC Teschendorff Andrew E AE Widschwendter Martin M
PLoS genetics 20120209 2
Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. Moreover, the role of DNA methylation for prediction of clinical outcome is still uncertain and confined to specific cancers. Here we perform the most comprehensive study of DNA methylation changes throughout human carcinogenesis, analysing 27,578 CpGs in each of 1,475 samples, ranging from normal cells in advance of non-invasive neoplastic tran ...[more]