DNA methylation changes in biomarker loci occur early in cancer progression.
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ABSTRACT:
SUBMITTER: Vrba L
PROVIDER: S-EPMC6993824 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
DNA methylation changes in biomarker loci occur early in cancer progression.
Vrba Lukas L Futscher Bernard W BW
F1000Research 20191216
Tumor-specific DNA methylation can be used for cancer diagnostics and monitoring. We have recently reported a set of DNA methylation biomarkers that can distinguish plasma samples from lung cancer patients versus healthy controls with high sensitivity and specificity. Furthermore, the DNA methylation signal from the biomarker loci detected in plasma samples correlated with tumor size and decreased after surgical resection of lung tumors. In order to determine the timing of DNA methylation of ...[more]
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