Ontology highlight
ABSTRACT:
SUBMITTER: Mergenthaler P
PROVIDER: S-EPMC3277118 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Mergenthaler Philipp P Kahl Anja A Kamitz Anne A van Laak Vincent V Stohlmann Katharina K Thomsen Susanne S Klawitter Heiko H Przesdzing Ingo I Neeb Lars L Freyer Dorette D Priller Josef J Collins Tony J TJ Megow Dirk D Dirnagl Ulrich U Andrews David W DW Meisel Andreas A
Proceedings of the National Academy of Sciences of the United States of America 20120110 5
The metabolic state of a cell is a key determinant in the decision to live and proliferate or to die. Consequently, balanced energy metabolism and the regulation of apoptosis are critical for the development and maintenance of differentiated organisms. Hypoxia occurs physiologically during development or exercise and pathologically in vascular disease, tumorigenesis, and inflammation, interfering with homeostatic metabolism. Here, we show that the hypoxia-inducible factor (HIF)-1-regulated glyco ...[more]