Ontology highlight
ABSTRACT:
SUBMITTER: Plavicki J
PROVIDER: S-EPMC3277119 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Plavicki Jessica J Mader Sara S Pueschel Eric E Peebles Patrick P Boekhoff-Falk Grace G
Proceedings of the National Academy of Sciences of the United States of America 20120117 5
Vertebrate Dlx genes have been implicated in the differentiation of multiple neuronal subtypes, including cortical GABAergic interneurons, and mutations in Dlx genes have been linked to clinical conditions such as epilepsy and autism. Here we show that the single Drosophila Dlx homolog, distal-less, is required both to specify chemosensory neurons and to regulate the morphologies of their axons and dendrites. We establish that distal-less is necessary for development of the mushroom body, a brai ...[more]