Ontology highlight
ABSTRACT:
SUBMITTER: Dixon RE
PROVIDER: S-EPMC3277143 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Dixon Rose E RE Yuan Can C Cheng Edward P EP Navedo Manuel F MF Santana Luis F LF
Proceedings of the National Academy of Sciences of the United States of America 20120117 5
Ca(2+) influx via L-type Ca(v)1.2 channels is essential for multiple physiological processes, including gene expression, excitability, and contraction. Amplification of the Ca(2+) signals produced by the opening of these channels is a hallmark of many intracellular signaling cascades, including excitation-contraction coupling in heart. Using optogenetic approaches, we discovered that Ca(v)1.2 channels form clusters of varied sizes in ventricular myocytes. Physical interaction between these chann ...[more]