Ontology highlight
ABSTRACT:
SUBMITTER: Bijlenga P
PROVIDER: S-EPMC16596 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Bijlenga P P Liu J H JH Espinos E E Haenggeli C A CA Fischer-Lougheed J J Bader C R CR Bernheim L L
Proceedings of the National Academy of Sciences of the United States of America 20000601 13
Mechanisms underlying Ca(2+) signaling during human myoblast terminal differentiation were studied using cell cultures. We found that T-type Ca(2+) channels (T-channels) are expressed in myoblasts just before fusion. Their inhibition by amiloride or Ni(2+) suppresses fusion and prevents an intracellular Ca(2+) concentration increase normally observed at the onset of fusion. The use of antisense oligonucleotides indicates that the functional T-channels are formed by alpha1H subunits. At hyperpola ...[more]