Ontology highlight
ABSTRACT:
SUBMITTER: Ocampo SM
PROVIDER: S-EPMC3277229 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ocampo Sandra M SM Romero Carolina C Aviñó Anna A Burgueño Joan J Gassull Miguel A MA Bermúdez Jordi J Eritja Ramon R Fernandez Ester E Perales Jose C JC
Molecular therapy : the journal of the American Society of Gene Therapy 20111101 2
Tumor necrosis factor (TNFα) is a proinflammatory cytokine involved in the pathogenesis of inflammatory bowel disease (IBD). Although TNFα has been extensively targeted using systemic drugs, the use of antisense and small interfering RNA (siRNA) to drive down its expression at the site of inflammation should provide important advantages. In this study, native and chemically modified siRNA against TNFα was developed and characterized using a murine model of IBD. siRNA with 2'-O-methyl and propane ...[more]