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Intermolecular Ritter-type C-H amination of unactivated sp3 carbons.

ABSTRACT: Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C-H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.

SUBMITTER: Michaudel Q

PROVIDER: S-EPMC3277284 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Intermolecular Ritter-type C-H amination of unactivated sp3 carbons.

Michaudel Quentin Q Thevenet Damien D Baran Phil S PS

Journal of the American Chemical Society 20120127 5

Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C-H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation ...[more]

PMID: 22276612

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