Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura Y
PROVIDER: S-EPMC3277310 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Nakamura Yoko Y Tagawa Kazuhiko K Oka Tsutomu T Sasabe Toshikazu T Ito Hikaru H Shiwaku Hiroki H La Spada Albert R AR Okazawa Hitoshi H
Human molecular genetics 20111118 5
The spinocerebellar ataxia type 7 (SCA7) gene product, Ataxin-7 (ATXN7), localizes to the nucleus and has been shown to function as a component of the TATA-binding protein-free TAF-containing-SPT3-TAF9-GCN5-acetyltransferase transcription complex, although cytoplasmic localization of ATXN7 in affected neurons of human SCA7 patients has also been detected. Here, we define a physiological function for cytoplasmic ATXN7. Live imaging reveals that the intracellular distribution of ATXN7 dynamically ...[more]