Ontology highlight
ABSTRACT:
SUBMITTER: McGann PT
PROVIDER: S-EPMC3277805 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
McGann Patrick T PT Flanagan Jonathan M JM Howard Thad A TA Dertinger Stephen D SD He Jin J Kulharya Anita S AS Thompson Bruce W BW Ware Russell E RE
Pediatric blood & cancer 20111019 2
<h4>Background</h4>The laboratory and clinical benefits of hydroxyurea therapy for children with sickle cell anemia (SCA) are well recognized, but treatment in young patients is limited in part by concerns about long-term genotoxicity, and specifically possible carcinogenicity.<h4>Procedure</h4>The Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) was a multicenter double-blinded placebo-controlled randomized clinical trial (NCT00006400) testing whether hydroxyurea could prevent chronic ...[more]