Ontology highlight
ABSTRACT:
SUBMITTER: Ware RE
PROVIDER: S-EPMC4755353 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Ware Russell E RE Rees Renee C RC Sarnaik Sharada A SA Iyer Rathi V RV Alvarez Ofelia A OA Casella James F JF Shulkin Barry L BL Shalaby-Rana Eglal E Strife C Frederic CF Miller John H JH Lane Peter A PA Wang Winfred C WC Miller Scott T ST
The Journal of pediatrics 20100101 1
<h4>Objectives</h4>To examine the feasibility and accuracy of glomerular filtration rate (GFR) measurements in infants with sickle cell anemia (SCA).<h4>Study design</h4>The NHLBI/NICHD-sponsored Phase III randomized double-blinded placebo-controlled trial (BABY HUG) tests the hypothesis that hydroxyurea can prevent chronic organ damage in SCA. GFR elevation is a coprimary endpoint, measured quantitatively by technetium 99m-labeled diethylenetriaminepentaacetic acid (DTPA) plasma clearance and e ...[more]