Ontology highlight
ABSTRACT:
SUBMITTER: Shao S
PROVIDER: S-EPMC3277827 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Shao Sichen S Hegde Ramanujan S RS
Cell 20111201 7
Metazoans secrete an extensive array of small proteins essential for intercellular communication, defense, and physiologic regulation. Their synthesis takes mere seconds, leaving minimal time for recognition by the machinery for cotranslational protein translocation into the ER. The pathway taken by these substrates to enter the ER is not known. Here, we show that both in vivo and in vitro, small secretory proteins can enter the ER posttranslationally via a transient cytosolic intermediate. This ...[more]