Ontology highlight
ABSTRACT:
SUBMITTER: Goh GB
PROVIDER: S-EPMC3277849 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Goh Garrett B GB Knight Jennifer L JL Brooks Charles L CL
Journal of chemical theory and computation 20120101 1
The nucleosides of adenine and cytosine have pKa values of 3.50 and 4.08, respectively, and are assumed to be unprotonated under physiological conditions. However, evidence from recent NMR and X-Ray crystallography studies has revealed the prevalence of protonated adenine and cytosine in RNA macromolecules. Such nucleotides with elevated pKa values may play a role in stabilizing RNA structure and participate in the mechanism of ribozyme catalysis. With the work presented here, we establish the f ...[more]