Ontology highlight
ABSTRACT:
SUBMITTER: Magalhaes PR
PROVIDER: S-EPMC4423061 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Biophysical journal 20150501 9
To our knowledge, we present the first constant-pH molecular dynamics study of the neuropeptide kyotorphin in the presence of an explicit lipid bilayer. The overall conformation freedom of the peptide was found to be affected by the interaction with the membrane, in accordance with previous results using different methodologies. Analysis of the interactions between the N-terminus amine group of the peptide and several lipid atoms shows that the membrane is able to stabilize both ionized and neut ...[more]