Novel redox-sensing modules: accessory protein- and nucleic acid-mediated signaling.

ABSTRACT:

Significance

Organisms have evolved both enzymatic and nonenzymatic pathways to prevent oxidative damage to essential macromolecules, including proteins and nucleic acids. Pathways modulated by different protein-based sensory and regulatory modules ensure a rapid and appropriate response.

Recent advances

In contrast to classical two-component systems that possess internal sensory and regulatory modules, an accessory protein-dependent redox-signaling system has been recently characterized in bacteria. This system senses extracellular iron-mediated oxidative stress signals via an extracellularly located protein (HbpS). In vivo and in vitro studies allowed the elucidation of molecular mechanisms governing this system. Moreover, recent studies show that nucleic acids may also pa

SUBMITTER: Siedenburg G 

PROVIDER: S-EPMC3277925 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature