Ontology highlight
ABSTRACT:
SUBMITTER: Lominac WJ
PROVIDER: S-EPMC3278155 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Lominac William J WJ D'Angelo Megan L ML Smith Mark D MD Ollison Darius A DA Hanna James M JM
Tetrahedron letters 20120201 8
3-Acylpyridine N-oxide tosylhydrazones give good overall yields of a mixture of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines when treated with an electrophilic additive and an amine base. (Z)-Hydrazones cyclize readily, while (E)-hydrazones fail to react under the reported conditions. The reaction takes place at room temperature, and moderate regiocontrol over the cyclization can be achieved by varying the electrophile/solvent combination. ...[more]