Ontology highlight
ABSTRACT:
SUBMITTER: Rotem D
PROVIDER: S-EPMC3278221 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Rotem Dvir D Jayasinghe Lakmal L Salichou Maria M Bayley Hagan H
Journal of the American Chemical Society 20120126 5
Protein nanopores have been used as stochastic sensors for the detection of analytes that range from small molecules to proteins. In this approach, individual analyte molecules modulate the ionic current flowing through a single nanopore. Here, a new type of stochastic sensor based on an αHL pore modified with an aptamer is described. The aptamer is bound to the pore by hybridization to an oligonucleotide that is attached covalently through a disulfide bond to a single cysteine residue near a mo ...[more]