Unknown

Dataset Information

0

The polypill in the primary prevention of cardiovascular disease: cost-effectiveness in the Dutch population.


ABSTRACT: Objectives The aim of the present study was to estimate the cost-effectiveness of the polypill in the primary prevention of cardiovascular disease. Design A health economic modelling study. Setting Primary healthcare in the Netherlands. Participants Simulated individuals from the general Dutch population, aged 45-75 years. Interventions Opportunistic screening followed by prescription of the polypill to eligible individuals. Eligibility was defined as having a minimum 10-year risk of cardiovascular death as assessed with the Systematic Coronary Risk Evaluation function of alternatively 5%, 7.5% or 10%. Different versions of the polypill were considered, depending on composition: (1) the Indian polycap, with three different types of blood pressure-lowering drugs, a statin and aspirin; (2) as (1) but without aspirin and (3) as (2) but with a double statin dose. In addition, a scenario of (targeted) separate antihypertensive and/or statin medication was simulated. Primary outcome measures Cases of acute myocardial infarction or stroke prevented, quality-adjusted life years (QALYs) gained and the costs per QALY gained. All interventions were compared with usual care. Results All scenarios were cost-effective with an incremental cost-effectiveness ratio between €7900 and 12?300 per QALY compared with usual care. Most health gains were achieved with the polypill without aspirin and containing a double dose of statins. With a 10-year risk of 7.5% as the threshold, this pill would prevent approximately 3.5% of all cardiovascular events. Conclusions Opportunistic screening based on global cardiovascular risk assessment followed by polypill prescription to those with increased risk offers a cost-effective strategy. Most health gain is achieved by the polypill without aspirin and a double statin dose.

SUBMITTER: van Gils PF 

PROVIDER: S-EPMC3278482 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

altmetric image

Publications

The polypill in the primary prevention of cardiovascular disease: cost-effectiveness in the Dutch population.

van Gils Paul F PF   Over Eelco A B EA   Hamberg-van Reenen Heleen H HH   de Wit G Ardine GA   van den Berg Matthijs M   Schuit Albertine J AJ   Engelfriet Peter M PM  

BMJ open 20111221 2


Objectives The aim of the present study was to estimate the cost-effectiveness of the polypill in the primary prevention of cardiovascular disease. Design A health economic modelling study. Setting Primary healthcare in the Netherlands. Participants Simulated individuals from the general Dutch population, aged 45-75 years. Interventions Opportunistic screening followed by prescription of the polypill to eligible individuals. Eligibility was defined as having a minimum 10-year risk of cardiov  ...[more]

Similar Datasets

| S-EPMC9333258 | biostudies-literature
| S-EPMC6938029 | biostudies-literature
| S-EPMC5584935 | biostudies-literature
| S-EPMC3688058 | biostudies-literature
| S-EPMC3023675 | biostudies-literature
| S-EPMC4845274 | biostudies-literature
| S-EPMC3145836 | biostudies-literature
| S-EPMC9022692 | biostudies-literature
| S-EPMC4797634 | biostudies-literature
| S-EPMC5956949 | biostudies-other