Ontology highlight
ABSTRACT:
SUBMITTER: Xiang Y
PROVIDER: S-EPMC3278854 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Xiang Yi Y Seemann Joachim J Bisel Blaine B Punthambaker Sukanya S Wang Yanzhuang Y
The Journal of biological chemistry 20070611 30
In mammalian cells the Golgi apparatus undergoes an extensive disassembly process at the onset of mitosis that is believed to facilitate equal partitioning of this organelle into the two daughter cells. However, the underlying mechanisms for this fragmentation process are so far unclear. Here we have investigated the role of the ADP-ribosylation factor-1 (ARF1) in this process to determine whether Golgi fragmentation in mitosis is mediated by vesicle budding. ARF1 is a small GTPase that is requi ...[more]