Ontology highlight
ABSTRACT:
SUBMITTER: Prag G
PROVIDER: S-EPMC549010 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Prag Gali G Lee Sangho S Mattera Rafael R Arighi Cecilia N CN Beach Bridgette M BM Bonifacino Juan S JS Hurley James H JH
Proceedings of the National Academy of Sciences of the United States of America 20050208 7
The Golgi-localized, gamma-ear-containing, Arf (ADP-ribosylation factor)-binding (GGA) proteins are clathrin adaptors that mediate the sorting of transmembrane-cargo molecules at the trans-Golgi network and endosomes. Cargo proteins can be directed into the GGA pathway by at least two different types of sorting signals: acidic cluster-dileucine motifs and covalent modification by ubiquitin. The latter modification is recognized by the GGAs through binding to their GAT [GGA and TOM (target of Myb ...[more]