ErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer.
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ABSTRACT:
SUBMITTER: Mill CP
PROVIDER: S-EPMC3278901 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
ErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer.
Mill Christopher P CP Zordan Michael D MD Rothenberg S Michael SM Settleman Jeffrey J Leary James F JF Riese David J DJ
Genes & cancer 20110801 8
ErbB4 is a member of the ErbB family of receptor tyrosine kinases. This family includes ErbB2 (HER2/Neu), a validated therapeutic target in breast cancer. Several studies indicate that ErbB4 functions as a tumor suppressor in breast cancer, whereas others indicate that ErbB4 functions as an oncogene. Here the authors explore the context in which ErbB4 functions as an oncogene. Silencing expression of either ErbB2 or ErbB4 in breast tumor cell lines results in reduced stimulation of anchorage ind ...[more]
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