Ontology highlight
ABSTRACT:
SUBMITTER: Campo DS
PROVIDER: S-EPMC3279735 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Scientific reports 20120215
Vaccine development against hepatitis C virus (HCV) is hindered by poor understanding of factors defining cross-immunoreactivity among heterogeneous epitopes. Using synthetic peptides and mouse immunization as a model, we conducted a quantitative analysis of cross-immunoreactivity among variants of the HCV hypervariable region 1 (HVR1). Analysis of 26,883 immunological reactions among pairs of peptides showed that the distribution of cross-immunoreactivity among HVR1 variants was skewed, with an ...[more]