Ontology highlight
ABSTRACT:
SUBMITTER: DiMattia MA
PROVIDER: S-EPMC3544974 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
DiMattia Michael A MA Watts Norman R NR Stahl Stephen J SJ Grimes Jonathan M JM Steven Alasdair C AC Stuart David I DI Wingfield Paul T PT
Structure (London, England : 1993) 20121206 1
Chronic hepatitis B virus (HBV) infection afflicts millions worldwide with cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a nonparticulate variant of the protein (core antigen, HBcAg) that forms the building-blocks of capsids. HBeAg is not required for virion production, but is implicated in establishing immune tolerance and chronic infection. Here, we report the crystal structure of HBeAg, which clarifies how the short N-terminal propeptide of HBeA ...[more]