Ontology highlight
ABSTRACT:
SUBMITTER: Schwab N
PROVIDER: S-EPMC3280052 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Schwab N N Ulzheimer J C JC Fox R J RJ Schneider-Hohendorf T T Kieseier B C BC Monoranu C M CM Staugaitis S M SM Welch W W Jilek S S Du Pasquier R A RA Brück W W Toyka K V KV Ransohoff R M RM Wiendl H H
Neurology 20120201 7
<h4>Objectives</h4>Progressive multifocal leukoencephalopathy (PML) has become much more common with monoclonal antibody treatment for multiple sclerosis and other immune-mediated disorders.<h4>Methods</h4>We report 2 patients with severe psoriasis and fatal PML treated for ≥3 years with efalizumab, a neutralizing antibody to αLβ2-leukointegrin (LFA-1). In one patient, we conducted serial studies of peripheral blood and CSF including analyses of leukocyte phenotypes, migration ex vivo, and CDR3 ...[more]