Ontology highlight
ABSTRACT:
SUBMITTER: Hothorn M
PROVIDER: S-EPMC3280218 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Hothorn Michael M Belkhadir Youssef Y Dreux Marlene M Dabi Tsegaye T Noel Joseph P JP Wilson Ian A IA Chory Joanne J
Nature 20110612 7352
Polyhydroxylated steroids are regulators of body shape and size in higher organisms. In metazoans, intracellular receptors recognize these molecules. Plants, however, perceive steroids at membranes, using the membrane-integral receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1). Here we report the structure of the Arabidopsis thaliana BRI1 ligand-binding domain, determined by X-ray diffraction at 2.5 Å resolution. We find a superhelix of 25 twisted leucine-rich repeats (LRRs), an architecture t ...[more]