Ontology highlight
ABSTRACT:
SUBMITTER: Lammens T
PROVIDER: S-EPMC3280274 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lammens Tim T Swerts Katrien K Derycke Lara L De Craemer Annemie A De Brouwer Sara S De Preter Katleen K Van Roy Nadine N Vandesompele Jo J Speleman Frank F Philippé Jan J Benoit Yves Y Beiske Klaus K Bracke Marc M Laureys Geneviève G
PloS one 20120215 2
One of the first and most important steps in the metastatic cascade is the loss of cell-cell and cell-matrix interactions. N-cadherin, a crucial mediator of homotypic and heterotypic cell-cell interactions, might play a central role in the metastasis of neuroblastoma (NB), a solid tumor of neuroectodermal origin. Using Reverse Transcription Quantitative PCR (RT-qPCR), Western blot, immunocytochemistry and Tissue MicroArrays (TMA) we demonstrate the expression of N-cadherin in neuroblastoma tumor ...[more]