Ontology highlight
ABSTRACT:
SUBMITTER: Pandey N
PROVIDER: S-EPMC3280434 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Pandey Nishtha N Govardhan Savitha S Pathak Ravi Kant RK
Bioinformation 20111221 8
RecQ helicases feature multiple domains in their structure, of which the helicase domain, the RecQ-Ct domain and the HRDC domains are well conserved among the SF2 helicases. The helicase domain and the RecQ-Ct domain constitute the catalytic core of the enzyme. The domain interfaces are the DNA binding sites which display significant conformational changes in our molecular dynamics simulation studies. The preferred conformational states of the DNA bound and unbound forms of RecQ appear to be qui ...[more]