Dataset Information

Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.

ABSTRACT: Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N=324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.

SUBMITTER: Nees F

PROVIDER: S-EPMC3280646 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.

Nees Frauke F Tzschoppe Jelka J Patrick Christopher J CJ Vollstädt-Klein Sabine S Steiner Sabina S Poustka Luise L Banaschewski Tobias T Barker Gareth J GJ Büchel Christian C Conrod Patricia J PJ Garavan Hugh H Heinz Andreas A Gallinat Jürgen J Lathrop Mark M Mann Karl K Artiges Eric E Paus Tomas T Poline Jean-Baptiste JB Robbins Trevor W TW Rietschel Marcella M Smolka Michael N MN Spanagel Rainer R Struve Maren M Loth Eva E Schumann Gunter G Flor Herta H

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20111123 4

Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we ...[more]

PMID: 22113088

Similar Datasets

Project description:BackgroundAlcohol expectancies are beliefs regarding positive (e.g., tension reduction) or negative (e.g., loss of motor coordination) effects of alcohol. Based on Social Learning Theory, social media can influence alcohol expectancies in adolescents. In particular, problematic social media use - which can reflect elements of addiction, including mood modification, tolerance, withdrawal, conflict, and relapse - could be linked to alcohol expectancies. We aimed to determine the associations between problematic social media use and alcohol expectancies in a national (U.S.) cohort of 10-14-year-old early adolescents.MethodsWe analyzed cross-sectional data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 9,008) at the Year 2 assessment (2018-2020). Unadjusted and adjusted linear regression analyses were conducted to examine the associations between problematic social media use and alcohol expectancies (positive and negative), adjusting for race/ethnicity, sex, household income, parent education, sexual orientation, parental marital status, and study site. Furthermore, we computed marginal predicted probabilities to aid in interpreting findings.ResultsThe sample was 48.7% female and racially and ethnically diverse (43.0% non-White), with a mean age of 12.02 ± 0.66 years old. In models adjusted for confounders including both time spent on social media and problematic social media use, time spent on social media was not associated with positive or negative alcohol expectancies, but higher problematic social media use score was associated with higher positive (B = 0.045, 95% confidence interval [CI] 0.020-0.069) and negative (B = 0.072, 95% CI 0.043-0.101) alcohol expectancies scores.ConclusionProblematic social media use was associated with both positive and negative alcohol expectancies in a demographically diverse national sample of early adolescents in the U.S. Given the small effect sizes of the current study, future studies should further examine these relationships prospectively, as well as the mechanisms linking problematic social media use to alcohol expectancies and alcohol consumption. Because alcohol expectancies are modifiable and linked with alcohol initiation, they could be a target for future prevention efforts.

Dataset Information

Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.

Publications

Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets