Ontology highlight
ABSTRACT:
SUBMITTER: Choo YM
PROVIDER: S-EPMC3281132 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Choo Young Moo YM Lee Kwang Sik KS Yoon Hyung Joo HJ Qiu Yuling Y Wan Hu H Sohn Mi Ri MR Sohn Hung Dae HD Jin Byung Rae BR
PloS one 20120216 2
Bee venom is a rich source of pharmacologically active substances. In this study, we identified a bumblebee (Bombus ignitus) venom Kunitz-type serine protease inhibitor (Bi-KTI) that acts as a plasmin inhibitor. Bi-KTI showed no detectable inhibitory effect on factor Xa, thrombin, or tissue plasminogen activator. In contrast, Bi-KTI strongly inhibited plasmin, indicating that it acts as an antifibrinolytic agent; however, this inhibitory ability was two-fold weaker than that of aprotinin. The fi ...[more]