Ontology highlight
ABSTRACT:
SUBMITTER: Hwang SH
PROVIDER: S-EPMC3281519 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110405 8
A series of dual inhibitors containing a 1,5-diarylpyrazole and a urea were designed, synthesized, and evaluated as novel COX-2/sEH dual inhibitors in vitro using recombinant enzyme assays and in vivo using a lipopolysaccharide (LPS) induced model of pain in rats. The best inhibition potencies and selectivity for sEH and COX-2 over COX-1 were obtained with compounds (21b, 21i, and 21j) in which both the 1,5-diaryl-pyrazole group and the urea group are linked with a three-methylene group. Compoun ...[more]