Ontology highlight
ABSTRACT:
SUBMITTER: Keller TL
PROVIDER: S-EPMC3281520 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Nature chemical biology 20120212 3
Febrifugine, the bioactive constituent of one of the 50 fundamental herbs of traditional Chinese medicine, has been characterized for its therapeutic activity, though its molecular target has remained unknown. Febrifugine derivatives have been used to treat malaria, cancer, fibrosis and inflammatory disease. We recently demonstrated that halofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by ...[more]