Ontology highlight
ABSTRACT:
SUBMITTER: Kang H
PROVIDER: S-EPMC3281737 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Kang Hara H Davis-Dusenbery Brandi N BN Nguyen Peter H PH Lal Ashish A Lieberman Judy J Van Aelst Linda L Lagna Giorgio G Hata Akiko A
The Journal of biological chemistry 20111209 6
The bone morphogenetic protein 4 (BMP4) signaling pathway plays a critical role in the promotion and maintenance of the contractile phenotype in vascular smooth muscle cell (vSMC). Misexpression or inactivating mutations of the BMP receptor gene can lead to dedifferentiation of vSMC characterized by increased migration and proliferation that is linked to vascular proliferative disorders. Previously we demonstrated that vSMCs increase microRNA-21 (miR-21) biogenesis upon BMP4 treatment, which ind ...[more]