Ontology highlight
ABSTRACT:
SUBMITTER: Al-Herz W
PROVIDER: S-EPMC5354354 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Al-Herz Waleed W Chu Julia I JI van der Spek Jet J Raghupathy Raj R Massaad Michel J MJ Keles Sevgi S Biggs Catherine M CM Cockerton Lucinda L Chou Janet J Dbaibo Ghassan G Elisofon Scott A SA Hanna-Wakim Rima R Kim Heung Bae HB Lehmann Leslie E LE McDonald Douglas R DR Notarangelo Luigi D LD Veys Paul P Chatila Talal A TA Geha Raif S RS Gaspar H Bobby HB Pai Sung-Yun SY
The Journal of allergy and clinical immunology 20160406 3
<h4>Background</h4>Dedicator of cytokinesis 8 (DOCK8) deficiency can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). Reports of outcomes are still limited.<h4>Objective</h4>We sought to analyze the results of HSCT in patients with DOCK8 deficiency and report whether approaches resulting in mixed chimerism result in clinically relevant immune reconstitution.<h4>Methods</h4>We performed a retrospective chart review of 11 patients with DOCK8 deficiency and measured DOCK8 expr ...[more]