Ontology highlight
ABSTRACT:
SUBMITTER: Schneckenleithner C
PROVIDER: S-EPMC3282066 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Schneckenleithner Christine C Bago-Horvath Zsuzsanna Z Dolznig Helmut H Neugebauer Nina N Kollmann Karoline K Kolbe Thomas T Decker Thomas T Kerjaschki Dontscho D Wagner Kay-Uwe KU Müller Mathias M Stoiber Dagmar D Sexl Veronika V
Oncotarget 20111201 12
Multiparous Stat1-/- mice spontaneously develop mammary tumors with increased incidence: at an average age of 12 months, 55% of the animals suffer from mammary cancer, although the histopathology is heterogeneous. We consistently observed mosaic expression or down-regulation of STAT1 protein in wild-type mammary cancer evolving in the control group. Transplantation experiments show that tumorigenesis in Stat1-/- mice is partially influenced by impaired CTL mediated tumor surveillance. Additional ...[more]