Ontology highlight
ABSTRACT:
SUBMITTER: Satoh A
PROVIDER: S-EPMC3282115 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Satoh Ayano A Wang Yanzhuang Y Malsam Jörg J Beard Matthew B MB Warren Graham G
Traffic (Copenhagen, Denmark) 20030301 3
Members of the golgin family of coiled-coil proteins have been implicated in the tethering of vesicles to Golgi membranes and cisternal membranes to each other. Many also bind to rab GTPases. Golgin-84 is a membrane-anchored golgin that we now show binds preferentially to the GTP form of the rab1 GTPase. It is also present throughout the Golgi stack by immuno-EM. Antibodies to golgin-84 inhibit stacking of cisternal membranes in a cell-free assay for Golgi reassembly, whereas the cytoplasmic dom ...[more]