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Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility.

ABSTRACT: OBJECTIVE:To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. METHODS:We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping. RESULTS:The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155. CONCLUSION:The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.

SUBMITTER: Lee SH

PROVIDER: S-EPMC3283048 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility.

Lee Sun-Hee SH Lee Suman S

Clinical and experimental reproductive medicine 20110331 1

<h4>Objective</h4>To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility.<h4>Methods</h4>We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping.<h ...[more]

PMID: 22384411

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