Ontology highlight
ABSTRACT:
SUBMITTER: Knafo S
PROVIDER: S-EPMC3283560 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Knafo Shira S Venero César C Sánchez-Puelles Cristina C Pereda-Peréz Inmaculada I Franco Ana A Sandi Carmen C Suárez Luz M LM Solís José M JM Alonso-Nanclares Lidia L Martín Eduardo D ED Merino-Serrais Paula P Borcel Erika E Li Shizhong S Chen Yongshuo Y Gonzalez-Soriano Juncal J Berezin Vladimir V Bock Elisabeth E Defelipe Javier J Esteban José A JA
PLoS biology 20120221 2
Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from the neural cell adhesion molecule (NCAM) that enhances spatial learning and memory in rats. We have now investigated the cellular and molecular basis of this cognitive enhancement, using biochemical, morphological, electrophysiological, and be ...[more]