Ontology highlight
ABSTRACT:
SUBMITTER: Oliveira TY
PROVIDER: S-EPMC3285106 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Journal of immunological methods 20111018 1-2
Chromosomal translocations require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are involved in producing leukemias, lymphomas and sarcomas. Translocations are frequent, clonal and recurrent in mature B cell lymphomas, which bear a particularly high DNA damage burden by virtue of activation-induced cytidine deaminase (AID) expression. Despite the ubiquity of genomic rearrangements, the forces that underlie their genesis are not we ...[more]