A molecular mechanism for modulating plasma Zn speciation by fatty acids.
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ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC3285120 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
A molecular mechanism for modulating plasma Zn speciation by fatty acids.
Lu Jin J Stewart Alan J AJ Sleep Darrell D Sadler Peter J PJ Pinheiro Teresa J T TJ Blindauer Claudia A CA
Journal of the American Chemical Society 20120112 3
Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a mole ...[more]
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