Ontology highlight
ABSTRACT:
SUBMITTER: Coverdale JPC
PROVIDER: S-EPMC6372834 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Coverdale James P C JPC Khazaipoul Siavash S Arya Swati S Stewart Alan J AJ Blindauer Claudia A CA
Biochimica et biophysica acta. Molecular and cell biology of lipids 20180925 4
In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy s ...[more]