Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC3285272 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Cell 20120201 3
Budding of COPI-coated vesicles from Golgi membranes requires an Arf family G protein and the coatomer complex recruited from cytosol. Arf is also required with coatomer-related clathrin adaptor complexes to bud vesicles from the trans-Golgi network and endosomal compartments. To understand the structural basis for Arf-dependent recruitment of a vesicular coat to the membrane, we determined the structure of Arf1 bound to the γζ-COP subcomplex of coatomer. Structure-guided biochemical analysis re ...[more]