Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC3285312 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Zhou Zhaocai Z Du Xiulian X Cai Zheng Z Song Xiaomin X Zhang Hongtao H Mizuno Takako T Suzuki Emi E Yee Marla Rosanne MR Berezov Alan A Murali Ramachandran R Wu Shiaw-Lin SL Karger Barry L BL Greene Mark I MI Wang Qiang Q
The Journal of biological chemistry 20111214 8
The SUN (Sad1-UNC-84 homology) domain is conserved in a number of nuclear envelope proteins involved in nuclear migration, meiotic telomere tethering, and antiviral responses. The LINC (linker of nucleoskeleton and cytoskeleton) complex, formed by the SUN and the nesprin proteins at the nuclear envelope, serves as a mechanical linkage across the nuclear envelope. Here we report the crystal structure of the SUN2 protein SUN domain, which reveals a homotrimer. The SUN domain is sufficient to media ...[more]