Ontology highlight
ABSTRACT:
SUBMITTER: Horigome C
PROVIDER: S-EPMC3173793 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Horigome Chihiro C Okada Takafumi T Shimazu Kyoko K Gasser Susan M SM Mizuta Keiko K
The EMBO journal 20110805 18
Two interacting ribosome biogenesis factors, Ebp2 and Rrs1, associate with Mps3, an essential inner nuclear membrane protein. Both are found in foci along the nuclear periphery, like Mps3, as well as in the nucleolus. Temperature-sensitive ebp2 and rrs1 mutations that compromise ribosome biogenesis displace the mutant proteins from the nuclear rim and lead to a distorted nuclear shape. Mps3 is known to contribute to the S-phase anchoring of telomeres through its interaction with the silent infor ...[more]