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A mouse model of the most aggressive subgroup of human medulloblastoma.

ABSTRACT: Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and significantly differ from mouse models of the Sonic-Hedgehog- and WNT-disease subgroups. This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis.

SUBMITTER: Kawauchi D

PROVIDER: S-EPMC3285412 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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A mouse model of the most aggressive subgroup of human medulloblastoma.

Kawauchi Daisuke D Robinson Giles G Uziel Tamar T Gibson Paul P Rehg Jerold J Gao Cuilan C Finkelstein David D Qu Chunxu C Pounds Stanley S Ellison David W DW Gilbertson Richard J RJ Roussel Martine F MF

Cancer cell 20120201 2

Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those ...[more]

PMID: 22340591

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A mouse model of the most aggressive subgroup of human medulloblastoma

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