A neurophysiological-metabolic model for burst suppression.
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ABSTRACT:
SUBMITTER: Ching S
PROVIDER: S-EPMC3286963 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
A neurophysiological-metabolic model for burst suppression.
Ching Shinung S Purdon Patrick L PL Vijayan Sujith S Kopell Nancy J NJ Brown Emery N EN
Proceedings of the National Academy of Sciences of the United States of America 20120207 8
Burst suppression is an electroencepholagram (EEG) pattern in which high-voltage activity alternates with isoelectric quiescence. It is characteristic of an inactivated brain and is commonly observed at deep levels of general anesthesia, hypothermia, and in pathological conditions such as coma and early infantile encephalopathy. We propose a unifying mechanism for burst suppression that accounts for all of these conditions. By constructing a biophysical computational model, we show how the preva ...[more]
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