Subtype and pathway specific responses to anticancer compounds in breast cancer.
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ABSTRACT:
SUBMITTER: Heiser LM
PROVIDER: S-EPMC3286973 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Subtype and pathway specific responses to anticancer compounds in breast cancer.
Heiser Laura M LM Sadanandam Anguraj A Kuo Wen-Lin WL Benz Stephen C SC Goldstein Theodore C TC Ng Sam S Gibb William J WJ Wang Nicholas J NJ Ziyad Safiyyah S Tong Frances F Bayani Nora N Hu Zhi Z Billig Jessica I JI Dueregger Andrea A Lewis Sophia S Jakkula Lakshmi L Korkola James E JE Durinck Steffen S Pepin François F Guan Yinghui Y Purdom Elizabeth E Neuvial Pierre P Bengtsson Henrik H Wood Kenneth W KW Smith Peter G PG Vassilev Lyubomir T LT Hennessy Bryan T BT Greshock Joel J Bachman Kurtis E KE Hardwicke Mary Ann MA Park John W JW Marton Laurence J LJ Wolf Denise M DM Collisson Eric A EA Neve Richard M RM Mills Gordon B GB Speed Terence P TP Feiler Heidi S HS Wooster Richard F RF Haussler David D Stuart Joshua M JM Gray Joe W JW Spellman Paul T PT
Proceedings of the National Academy of Sciences of the United States of America 20111014 8
Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differenti ...[more]
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