Ontology highlight
ABSTRACT:
SUBMITTER: Khakabimamaghani S
PROVIDER: S-EPMC6872169 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Khakabimamaghani Sahand S Ding Dujian D Snow Oliver O Ester Martin M
PLoS computational biology 20191111 11
Cancer is driven by genetic mutations that dysregulate pathways important for proper cell function. Therefore, discovering these cancer pathways and their dysregulation order is key to understanding and treating cancer. However, the heterogeneity of mutations between different individuals makes this challenging and requires that cancer progression is studied in a subtype-specific way. To address this challenge, we provide a mathematical model, called Subtype-specific Pathway Linear Progression M ...[more]