Ontology highlight
ABSTRACT:
SUBMITTER: Gabrielsen M
PROVIDER: S-EPMC3288085 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Gabrielsen Mads M Beckham Katherine S H KS Feher Victoria A VA Zetterström Caroline E CE Wang Dai D Müller Sylke S Elofsson Mikael M Amaro Rommie E RE Byron Olwyn O Roe Andrew J AJ
PloS one 20120227 2
Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced states, together with the structure of the C61S mutant. The structures solved are consistent with previously solved atypical 2-Cys thiol peroxidases, including that for "forced" reduced states using the C61S mutant. In addition, by investigating the sol ...[more]